Abstract

Background: To examine whether periodontitis is associated with the presence and severity of radiographic knee osteoarthritis (OA).

Methods: Using data from the Korea National Health and Nutrition Examination Survey between 2010 and 2013, participants over the age of 50 were included in this study. Dental examinations and knee radiographs are performed in participants aged ≥50 years in this cohort. Periodontitis was defined using the community periodontal index, which was determined by measuring periodontal probing depth. The definition of adiographic knee OA was based on the Kellgren-Lawrence (K-L) grading system, which determined a K-L class ≥2 to be radiographic knee OA. The associations between periodontitis and presence and severity of radiographic knee OA were examined using logistic regression analyses.

Results: Among 7969 total participants, 965 men and 2078 women had radiographic knee OA. Periodontitis was observed in 1,185 (39.4%) people among those who had radiographic knee OA. Periodontitis (adjusted odds radio [aOR] 1.21, 95% confidence interval 1.05 to 1.40) was associated with radiographic knee OA after adjusting for variables including age, sex, body mass index, socioeconomic status, diabetes, and dental status. Participants were more likely to have radiographic knee OA as the severity of periodontitis increased (non-severe periodontitis, aOR 1.14 [0.98 to 1.32]; severe periodontitis, aOR 1.47 [1.17 to 1.85]). Moreover, the presence of periodontitis significantly increased with an increasing K-L class (class 1, aOR 1.30 [1.09 to .54]; class 2, aOR 1.32 [1.08 to 1.60]; class 3, aOR 1.39 [1.14 to 1.70]; class 4, aOR 1.45 [1.11 to 1.90]).

Conclusion: Periodontitis is associated with the presence and severity of radiographic knee OA.

背景：研究牙周炎是否与膝骨性关节炎(OA)的存在及严重程度有关。

方法：使用2010年至2013年韩国国家健康和营养检查调查的数据，50岁以上的参与者被纳入本研究中。在这个队列中，年龄≥50岁的参与者进行了牙科和膝关节x线片检查。牙周炎采用社区牙周指数进行定义，即通过测量牙周探诊深度来确定。膝关节骨性关节炎的定义基于Kellgren-Lawrence (K-L)分级系统，该分级系统判定K-L分级≥2为膝关节骨性关节炎。使用逻辑回归分析检查牙周炎与膝关节骨性关节炎的存在和严重程度之间的关系。

结果: 7969名参与者中，965名男性和2078名女性有膝关节骨性关节炎。1,185例(39.4%)膝关节骨性关节炎患者中观察到患有牙周炎。在调整了年龄、性别、体重指数、社会经济地位、糖尿病和牙齿状况等变量后，牙周炎(校正比值比[aOR] 1.21, 95%置信区间1.05至1.40)与膝关节骨性关节炎相关。随着牙周炎严重程度的增加，受试者更有可能发生膝关节骨性关节炎(非重度牙周炎，aOR 1.14 [0.98 ~ 1.32];重试牙周炎，aOR 1.47[1.17 - 1.85])。此外，随着K-L等级的增加，牙周炎的发病率显著增加(I级，aOR 1.30 [1.09 ~ .54]; II级,aOR 1.32[1.08至1.60];III级,aOR 1.39[1.14至1.70];IV级,aOR 1.45[1.11至1.90])。

结论: 牙周炎与膝关节骨性关节炎的存在及严重程度有关。